Discovery of novel double pyrazole Schiff base derivatives as anti-tobacco mosaic virus (TMV) agents
| Autor: | Dao-Hong Liu, Zi-Li Ren, Ming-Jie Chu, Xian-Hai Lv, Qing-Shan Li, Ban-Feng Ruan, Kai Mo, Haiqun Cao, Dong-Dong Li, Cheng-Ying Ai |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Schiff base 010405 organic chemistry Stereochemistry viruses fungi Nucleic acid sequence food and beverages General Chemistry Pyrazole 01 natural sciences Insert (molecular biology) 0104 chemical sciences 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Tobacco mosaic virus TMV chemistry Tobacco mosaic virus Bioassay Nucleotide |
| Zdroj: | Chinese Chemical Letters. 28:377-382 |
| ISSN: | 1001-8417 |
| DOI: | 10.1016/j.cclet.2016.10.029 |
| Popis: | Many pyrazole derivatives were reported to exhibit highly activity towards tobacco mosaic virus (TMV). In this work, an optimized pyrazole Schiff base scaffold was designed and introduced to derive novel potential TMV inhibitors. Thirty-six compounds were synthesized, characterized by elemental analysis, mass spectra and nuclear magnetic resonance (NMR) spectroscopy and evaluated by biological experiments. The bioassay results showed that some of the synthesized compounds exhibited excellent anti-TMV activities. Especially, 5-chloro-3-methyl-1H-pyrazole contained compound 4j showed ningnanmycin comparable inhibitory activity and can be considered as potential anti-TMV candidate agent. With molecular docking, compound 4j insert into nucleotide sequence (GAAGUU) of OriRNA stably which revealed nucleotide could be a target of these compounds. |
| Databáze: | OpenAIRE |
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