Efek pemberian propolis pada fungsi ginjal dan hepar tikus putih (Rattus Norvegicus) yang diinduksi cisplatin

Autor: Novriantika Lestari, Fajrianti Haniyah, Annisa Puspa Sari, Liya Agustin Umar, Elvira Yunita
Rok vydání: 2021
Předmět:
Zdroj: Intisari Sains Medis. 12:508-512
ISSN: 2503-3638
2089-9084
DOI: 10.15562/ism.v12i2.1017
Popis: Background: Cisplatin as an anticancer drug results in nephrotoxicity and hepatotoxicity. Accumulation of cisplatin in the body will produce reactive compounds in the form of free radicals which induce oxidative stress that affects kidney and liver functions. Propolis contains flavonoids, phenolic acid, and Caffeic Acid Phenethyl Ester (CAPE) which have the ability to prevent free radical formation and improve kidney and liver function. This study aims to determine the effect of propolis administration to ameliorate of BUN, creatinine, ALT and AST levels in cisplatin-induced rats (Rattus norvegicus).Methods: The experimental study was conducted with the pre-post-test with control group design approach. The research sample used 30 white rats which were divided into normal (aquadest), Cisplatin (5mg/kg i.p), and cisplatin+propolis groups. Propolis was given at a dose of 50mg/kg, 100mg/kg and 200mg/kg orally for seven days, four days after cisplatin induction. Rat blood was taken for analysis of Bloof Urea Nitrogen (BUN), Creatinine, ALT, and AST levels. Data were analyzed using SPSS version 26 for Windows.Results: The results showed that there were significant differences in levels of BUN, Creatinine, ALT and AST between groups (p
Databáze: OpenAIRE
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