Rabeprazole-based 3-day and 7-day triple therapy vs. omeprazole-based 7-day triple therapy for the treatment of Helicobacter pylori infection

Autor:	K. F. Li, P. Lau, Tsm Tong, Benjamin C.Y. Wong, Ming-Leung Szeto, Chee-Kin Hui, Sandi Lam, W. M. Wong, W. K. Hung, K. C. Lai, W. H. C. Hu, Man-Fung Yuen, Y. K. Yee, F. M. Y. Fung, A. W. C. Yip
Rok vydání:	2001
Předmět:	medicine.medical_specialty Hepatology biology medicine.drug_class business.industry Gastroenterology Rabeprazole Proton-pump inhibitor Pharmacology Amoxicillin Helicobacter pylori biology.organism_classification Pharmacotherapy Clarithromycin Internal medicine medicine Pharmacology (medical) business Omeprazole medicine.drug Antibacterial agent
Zdroj:	Alimentary Pharmacology & Therapeutics. 15:1959-1965
ISSN:	0269-2813
DOI:	10.1046/j.1365-2036.2001.01118.x
Popis:	Background: Rabeprazole is a new proton pump inhibitor with more potent acid suppressive and anti-Helicobacter effects. Aim: To compare two different regimens of rabeprazole-based triple therapy vs. 7-day omeprazole-based triple therapy for the eradication of Helicobacter pylori infection. Method: Patients with proven H. pylori infection were randomized to receive: (i) 7-day rabeprazole, 10 mg, amoxicillin, 1000 mg, and clarithromycin, 500 mg, all twice daily; (ii) 3-day rabeprazole, 20 mg, amoxicillin, 1000 mg, and clarithromycin, 500 mg, all twice daily; or (iii) 7-day omeprazole, 20 mg, amoxicillin, 1000 mg, and clarithromycin, 500 mg, all twice daily. Endoscopy (CLO test, histology) was performed before randomization and 6 weeks after drug treatment. Results: One hundred and seventy-three patients were randomized. H. pylori eradication rates (intention-to-treat, n=173/per protocol, n=167) were 88%/91% for 7-day rabeprazole-based therapy, 72%/72% for 3-day rabeprazole-based therapy and 82%/89% for 7-day omeprazole-based therapy, respectively. The per protocol eradication rate was significantly better in the 7-day rabeprazole-based therapy and 7-day omeprazole-based therapy groups when compared to the 3-day rabeprazole-based therapy group (P=0.01 and P=0.04, respectively). Compliance was excellent and all three regimens were well tolerated. Conclusions: The efficacy of seven-day rabeprazole-based triple therapy is similar to 7-day omeprazole-based triple therapy for the eradication of H. pylori infection.
Databáze:	OpenAIRE
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