Dietary Nitrate Increases VO2peak and Performance but Does Not Alter Ventilation or Efficiency in Patients With Heart Failure With Reduced Ejection Fraction
| Autor: | Indra Bole, Seth R. Broadstreet, Andrew R. Coggan, Deepak P. Thomas, Joshua L. Leibowitz, Kiran Mahmood, Ana Kadkhodayan, Linda R. Peterson, Michael T. Madigan, Deana Mikhalkova, Dakkota Thies, Soo Park |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Ejection fraction business.industry Population VO2 max 030204 cardiovascular system & hematology Beetroot Juice medicine.disease Crossover study 03 medical and health sciences 0302 clinical medicine Internal medicine Heart failure Breathing medicine Cardiology Ingestion Cardiology and Cardiovascular Medicine business education 030217 neurology & neurosurgery |
| Zdroj: | Journal of Cardiac Failure. 24:65-73 |
| ISSN: | 1071-9164 |
| Popis: | Background Patients with heart failure with reduced ejection fraction (HFrEF) exhibit lower efficiency, dyspnea, and diminished peak oxygen uptake (VO 2 peak) during exercise. Dietary nitrate (NO 3 − ), a source of nitric oxide (NO), has improved these measures in some studies of other populations. We determined the effects of acute NO 3 − ingestion on exercise responses in 8 patients with HFrEF using a randomized, double-blind, placebo-controlled, crossover design. Methods and Results Plasma NO 3 − , nitrite (NO 2 − ), and breath NO were measured at multiple time points and respiratory gas exchange was determined during exercise after ingestion of beetroot juice containing or devoid of 11.2 mmol of NO 3 − . NO 3 − intake increased ( P 3 − and NO 2 − and breath NO by 1469 ± 245%, 105 ± 34%, and 60 ± 18%, respectively. Efficiency and ventilation during exercise were unchanged. However, NO 3 − ingestion increased ( P 2 peak by 8 ± 2% (ie, from 21.4 ± 2.1 to 23.0 ± 2.3 mL . min −1. kg −1 ). Time to fatigue improved ( P Conclusions Acute dietary NO 3 − intake increases VO 2 peak and performance in patients with HFrEF. These data, in conjunction with our recent data demonstrating that dietary NO 3 − also improves muscle contractile function, suggest that dietary NO 3 − supplementation may be a valuable means of enhancing exercise capacity in this population. |
| Databáze: | OpenAIRE |
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