Synthesis of isothiochroman 2,2-dioxide and 1,2-benzooxathiin 2,2-dioxide gyrase B inhibitors

Autor:	Patrick Laurin, Pascale Mauvais, Alain Bonnefoy, Michel Klich, Patrice Lassaigne, Claudine Dupuis-Hamelin, Branislav Musicki, Christophe Peixoto
Rok vydání:	2000
Předmět:	Stereochemistry Chemistry Organic Chemistry Coumarin Biochemistry Combinatorial chemistry DNA gyrase In vitro Isothiochroman chemistry.chemical_compound Inhibitory potency Drug Discovery DNA supercoil heterocyclic compounds Biological evaluation
Zdroj:	Tetrahedron Letters. 41:1741-1745
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)00044-7
Popis:	The design, synthesis and in vitro biological evaluation of isothiochroman 2,2-dioxide and 1,2-benzooxathiin 2,2-dioxide analogues of coumarin inhibitors of gyrase B are described. Compared to coumarin derivatives, compounds of the 1,2-benzooxathiin 2,2-dioxide series display improved inhibitory potency in negative supercoiling of relaxed DNA gyrase.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3061360d1ba9cf6259ea4012083b9848 https://doi.org/10.1016/s0040-4039(00)00044-7 Zobrazit plný text záznamu Full Text from ScienceDirect