| Autor: |
Nigel P. M. Sacks, Anthony R Hyett |
| Rok vydání: |
2001 |
| Předmět: |
|
| Zdroj: |
British Menopause Society Journal. 7:16-19 |
| ISSN: |
1362-1807 |
| DOI: |
10.1258/136218001100321074 |
| Popis: |
The exact incidence of new breast symptoms with hormone replacement therapy (HRT) and its trophic effects on benign breast disorders is not well quantified and remains relatively understudied. This is a rapidly growing clinical issue as the rate of HRT use is increasing. Significant mastalgia with breast tenderness, mammographic changes and benign and premalignant breast proliferative epithelial diseases with and without atypia are common with HRT. Mammographic sensitivity and specificity are decreased by the increased focal and diffuse mammographic density caused by oestrogen and/or progestogen. There is a widely perceived but incorrect belief that progestogens are beneficial for the breast in terms of symptoms and breast cancer risk; however, the opposite now appears to be the case. The small but significant risk of the diagnosis of invasive breast cancer with HRT has diverted attention in the medical literature away from the actual increase in the incidence of benign breast disease. This is well and truly counter-balanced by the many proven important health benefits of therapy in postmenopausal women including prevention of osteoporosis and improved quality of life. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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