Adult schizotypal personality characteristics and prenatal influenza in a Finnish birth cohort
| Autor: | Antti Tanskanen, Reijo Pyhälä, Sarnoff A. Mednick, Jennifer Bunn Watson, Ricardo A. Machon, Markus Henriksson, M. Huttunen, Juhani Sinivuo |
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| Rok vydání: | 2002 |
| Předmět: |
Pediatrics
medicine.medical_specialty media_common.quotation_subject medicine.disease Schizotypal personality disorder 030227 psychiatry 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Neurodevelopmental disorder Schizophrenia medicine Etiology Personality Gestation Young adult Psychology 030217 neurology & neurosurgery Biological Psychiatry media_common Cohort study |
| Zdroj: | Schizophrenia Research. 54:7-16 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/s0920-9964(01)00346-2 |
| Popis: | Recent evidence suggests that schizophrenia may result from a disruption of normal brain development during a critical, prenatal risk period in the 6th month of gestation. The phenotypic diagnostic manifestation of a basic genetic–neurodevelopmental disorder may consist of characteristics approximated by the DSM-IV diagnosis of “schizotypal personality disorder” (SPD). We identified male conscripts in Finland who, as fetuses, were exposed to the 1969 Hong Kong Influenza epidemic, along with a group of controls born during a relatively low year (1971) for infectious epidemics. It was hypothesized that among fetuses exposed to the influenza epidemic in their 6th month of gestation, we would observe an increased frequency of elevated (upper quartile) scores on a schizotypal personality characteristics (SPC) scale as compared to controls. A significantly higher proportion of the 6th month index exposed subjects (39%) had “elevated” SPC scale scores as compared to their controls (26%) (p |
| Databáze: | OpenAIRE |
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