Antimicrobial susceptibility patterns and MICs among non-photochromogenic rapidly growing Mycobacteroides and Mycolicibacterium species
| Autor: | Yoshikazu Inoue, Satoshi Mitarai, Shiomi Yoshida, Katsuhiro Suzuki, Kinuyo Chikamatsu, Kazunari Tsuyuguchi, Akiko Takaki, Akio Aono, Takehiko Kobayashi |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Antiinfective agent medicine.drug_class fungi 030106 microbiology Erythromycin General Medicine Drug resistance Biology Antimicrobial Microbiology Meropenem Macrolide Antibiotics 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology chemistry Amikacin Linezolid medicine medicine.drug |
| Zdroj: | Journal of Medical Microbiology. 68:1279-1286 |
| ISSN: | 1473-5644 0022-2615 |
| Popis: | Introduction. Non-photochromogenic rapidly growing mycobacteria (NPRGM) that branch distinctly from Mycobacteroides (Myco) and Mycolicibacterium (Mycolici) are increasingly observed clinically and present a complicated treatment challenge; thus, appropriate in vitro susceptibility testing is required. Methodology. We evaluated the MICs of nine antimicrobials used in the treatment of infections of 25 NPRGM type strains. The relation of inducible macrolide resistance with functional erythromycin ribosomal methylase (erm) genes was also investigated. Results. The initial clarithromycin MIC reading at 3 days showed resistance in four of the Mycolici strains. In contrast, the presence of erm genes among Mycolici species differed from previous findings. Both Myco and Mycolici species were highly susceptible to amikacin and linezolid. Myco species were resistant to fluoroquinolones, while Mycolici species were susceptible. Meropenem showed low activity against Myco species, but high activity against Mycolici species. Conclusion. NPRGM clade-specific susceptibility patterns suggest an urgent need to establish distinct breakpoints for Myco and Mycolici species. |
| Databáze: | OpenAIRE |
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