Further tests for linkage of bipolar affective disorder to the tyrosine hydroxylase gene locus on chromosome 11p15 in a new series of multiplex British affective disorder pedigrees [published erratum appears in Am J Psychiatry 1997 Jan;154(1):139]

Autor: Jane O'Neill, David Curtis, Robin Sherrington, Larry Rifkin, Hannes Petursson, Hugh Gurling, Gursharan Kalsi, Patrick B. Murphy, E Moloney, J Brynjolfsson, C Smyth
Rok vydání: 1996
Předmět:
Zdroj: American Journal of Psychiatry. 153:271-274
ISSN: 1535-7228
0002-953X
DOI: 10.1176/ajp.153.2.271
Popis: Objective : This study was undertaken to confirm or refute previous reports that link bipolar affective disorder to polymorphic DNA markers at or near the gene for tyrosine hydroxylase. Method : A previous linkage analysis, which used a tetranucleotide repeat polymorphism at the tyrosine hydroxylase locus, of six Icelandic families was extended to include a new series of 17 multiply affected British families. Results : Overall lod scores under the assumption of locus heterogeneity were between 1.20 and 1.40 at zero recombination with tyrosine hydroxylase, and these scores persisted across three affective disorder models. Conclusions : These results provide some support for linking affective disorder to this genetic region and suggest that additional linkage and association studies should be conducted to determine whether tyrosine hydroxylase or a nearby locus contributes to susceptibility to bipolar affective disorder in some families.
Databáze: OpenAIRE