Retrospective Resistance Pattern of Clinical Isolates In Vitro Against Imipenem and Other Antimicrobial Agents Between 1986 and 1989
| Autor: | Nösner K, Klietmann W, J. Focht |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Imipenem
medicine.drug_class Aerobic bacteria Cephalosporin Pseudomonas General Medicine biochemical phenomena metabolism and nutrition Biology bacterial infections and mycoses biology.organism_classification Antimicrobial Microbiology polycyclic compounds medicine Pharmacology (medical) Ofloxacin Anaerobic bacteria medicine.drug Piperacillin |
| Zdroj: | Drug Investigation. 3:270-277 |
| ISSN: | 1179-1918 0114-2402 |
| DOI: | 10.1007/bf03259577 |
| Popis: | The in vitro activity of imipenem and several other antibacterial agents (including broad spectrum penicillins, expanded spectrum cephalosporins, and fluoroquinolones) was assessed against 130 033 clinical isolates of Gram-negative aerobic bacteria, Gram-positive aerobic bacteria, and anaerobic bacteria, collected in Germany between 1986 and 1989. Overall, 97.4% of the isolates were inhibited by an imipenem concentration of 4 mg/L. Most isolates of Xanthomonas maltophilia and Pseudomonas cepacia were resistant to imipenem between 1986 and 1989. However, when these 2 species are excluded, the frequency of resistance of the remaining isolates is < 1% each for Gram-negative, Gram-positive, and anaerobic species, indicating a level of activity of imipenem greater than that of any of the 18 comparative antibacterial agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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