Soluble KDI domain of γ1 laminin protects adult hippocampus from excitotoxicity of kainic acid
| Autor: | Pekka Rauhala, Päivi Liesi, Markus Wiksten, Ron Liebkind, Antti J. Väänänen |
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| Rok vydání: | 2004 |
| Předmět: |
0303 health sciences
Kainic acid biology Neurite Central nervous system Excitotoxicity Hippocampus Hippocampal formation medicine.disease_cause 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine medicine.anatomical_structure nervous system Gliosis chemistry Laminin biology.protein medicine medicine.symptom Neuroscience 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Journal of Neuroscience Research. 78:411-419 |
| ISSN: | 0360-4012 |
| DOI: | 10.1002/jnr.20158 |
| Popis: | Recent data indicate that the soluble KDI domain of γ1 laminin promotes survival and neurite outgrowth of human central neurons in vitro (Liebkind et al.[2003] J Neurosci Res 73:637–643), and seems to neutralize both glia- and myelin-derived signals that hamper regeneration in the central nervous system (CNS) of adult mammals. We show that damage of adult rat neocortical and hippocampal areas by a stereotaxic injection of kainic acid (KA) is prevented by a preceding injection of the soluble KDI domain. In the presence of the KDI domain, both neocortical and hippocampal areas show extensive gliosis but have viable neurons and glial cells, which are absent and the areas fully destroyed after injection of KA alone. This result indicates that the KDI domain of the γ1 laminin protects the CNS against excitotoxic insults and promotes survival of both neurons and glial cells. The KDI domain may thus be a potential drug to prevent CNS damage induced by neurodegenerative disorders, mechanical injury, or ischemia. © 2004 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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