Targeted Inactivation of the Gene Encoding Gamma-Synuclein Affects Anxiety Levels and Investigative Activity in Mice

Autor:	V. S. Kokhan, Tatyana A. Shelkovnikova, Natalia Ninkina, Vladimir L. Buchman, Sergey O. Bachurin, Alexei Bolkunov, Tatyana Strekalova, G. I. Van'kin, O. M. Redkozubova, A. A. Ustiugov
Rok vydání:	2012
Předmět:	γ synuclein animal diseases General Neuroscience Gamma-synuclein Context (language use) nervous system diseases nervous system Cytoplasm mental disorders medicine Synuclein Anxiety medicine.symptom Psychology Neuroscience Gene
Zdroj:	Neuroscience and Behavioral Physiology. 42:575-581
ISSN:	1573-899X 0097-0549
DOI:	10.1007/s11055-012-9603-1
Popis:	Gamma (γ) synuclein is a member of the family of synucleins, which are cytoplasmic, predominantly, neuronal, proteins found only in vertebrates. Significant quantities of γ-synuclein are found in the axons and presynaptic terminals of neurons located in brain areas responsible for forming emotions and memory. However, the involvement of γ-synucleins in controlling neuronal and synaptic processes underlying various types of behavior in humans and animals have not yet been studied. We provide the first demonstration that the absence of γ-synuclein increases orientational-investigative activity in a novel context and decreases the level of situational anxiety in animals.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::301c52120eb7dc5cf6e224cbaa85403b https://doi.org/10.1007/s11055-012-9603-1 Zobrazit plný text záznamu Full text from SpringerLink