Anti-Inflammatory Activity and Sub-Acute Toxicity of Artemetin1
| Autor: | Raymond Zelnik, Amabile K. Matida, Jayme Antonio Aboin Sertié, Aulus Conrado Basile, S Panizza |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Pharmacology
Traditional medicine medicine.drug_class Organic Chemistry Pharmaceutical Science chemistry.chemical_element Vascular permeability Biological activity Biology Calcium Anti-inflammatory Analytical Chemistry chemistry.chemical_compound Complementary and alternative medicine chemistry Drug Discovery Toxicity Phenylbutazone medicine Molecular Medicine Histamine ED50 medicine.drug |
| Zdroj: | Planta Medica. 56:36-40 |
| ISSN: | 1439-0221 0032-0943 |
| Popis: | The 5-hydroxy-3,6,7,3',4'-pentamethoxyflavone (artemetin) from Cordia verbenacea DC (Boraginaceae) showed marked anti-inflammatory activity using various experimental models in rats. Artemetin significantly inhibited carrageenin-induced paw edema following oral doses from 30.4 to 153.9 mg.kg-1. The doses of 102.6 and 153.9 mg.kg-1 showed an inhibitory effect similar to that of 50.0 mg.kg-1 of calcium phenylbutazone. The ED50 value of artemetin in rats was estimated to be 67.07 mg.kg-1. Repeated administration of artemetin at doses of 67.07 mg.kg-1 for a 6-day period reduced granuloma formation with a response comparable to that of 20.0 mg.kg-1 of calcium phenylbutazone. This same dose of artemetin also reduced the vascular permeability to intracutaneous histamine. Sub-acute toxicological experiments indicated a very low toxicity. |
| Databáze: | OpenAIRE |
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