PREVELANC OF HYPONATREMIA AND ITS ASSOCIATION WITH DEVELOPMENT AND SEVERITY OF COMPLICATIONS IN CIRRHOTIC PATIENTS
| Autor: | Sayed Al-nahal, Abdallah Abdel-aziz, Amir M Elokely, Nevein G. Mikheil, Osama A. Khalil |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Cirrhosis business.industry nutritional and metabolic diseases medicine.disease Gastroenterology Surgery Liver disease Spontaneous bacterial peritonitis Esophageal varices Hepatorenal syndrome Internal medicine Ascites medicine medicine.symptom business Hyponatremia Hepatic encephalopathy |
| Zdroj: | Zagazig University Medical Journal. 19:1-8 |
| ISSN: | 2357-0717 |
| DOI: | 10.21608/zumj.2013.4299 |
| Popis: | Hyponatremia is common in advanced liver cirrhosis. Recently it has attracted an interest as a possible prognostic factor for liver cirrhosis complications. This study was conducted to assess the prevalence of hyponatremia in complicated cirrhotic patients admitted to medical ICU and to identify its relationship to development and severity of these complications. 200 patients with liver cirrhosis were included in this study. According to serum sodium, they were classified into three groups: group 1 with serum sodium ≤130 meq/L (severe hyponatremia), group 2 with serum sodium from 131 to 135 meq/L (mild hyponatremia) and group 3 with serum sodium ≥136 meq/L (normo-natremia). Demographic, clinical, and laboratory variables were prospectively recorded for analysis. In our studyThe prevalence of total hyponatremia was 131/200 patients (65.5%) and those with severe hyponatremia were 91/200 (45.5%) .There was a statistically significant increase in frequency of occurance (p>0.01) and relative risk each of ascites (1.3fold),intractable ascites (9.5fold), spontaneous bacterial peritonitis (2.6fold), hepatic hydrothorax (1.5fold) and hepatic encephalopathy (2.8fold), in hyponatremic groups compared to normonatremic one while there was no significant difference regarding hepatorenal syndrome, esophageal varices and variceal bleeding between different groups. Also there was a statistically significant negative correlation betwee serum sodium level and the two scoring systems: Child-Pugh score (r =-0.690, p |
| Databáze: | OpenAIRE |
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