Serum hyaluronate level correlates to the degree of liver fibrosis in pediatric liver diseases
| Autor: | Takuji Fujisawa, Hirohisa Kato, Masayoshi Kage, Masamichi Kojiro, Eisuke Nakashima |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Pathology
medicine.medical_specialty Hepatology medicine.diagnostic_test business.industry medicine.disease Lesion chemistry.chemical_compound Infectious Diseases chemistry Hyaluronate lyase Fibrosis Liver biopsy Biopsy medicine Sampling (medicine) Liver function medicine.symptom business Sirius Red |
| Zdroj: | Hepatology Research. 16:59-67 |
| ISSN: | 1386-6346 |
| DOI: | 10.1016/s1386-6346(99)00039-x |
| Popis: | Usefulness of monitoring a serum marker for liver fibrosis, hyaluronate, for various pediatric liver diseases was examined. Subjects were 73 children who had been followed in the Department of Pediatrics and Child Health, Kurume University School of Medicine for liver function disorders, and who received liver biopsy and serum sampling. Serum hyaluronate levels were measured by using the sandwich binding protein assay system. Collagen fibers in each biopsy specimen were stained with Sirius red, and the amount of the stained fibers were measured by a computer image analysis system in order to obtain the degree of fibrosis, i.e. ratio of the area of collagen fibers to the entire liver specimen. Pearson’s correlation coefficient and regression analysis revealed a significant correlation between the serum hyaluronate level and degree of fibrosis (r=0.687, P |
| Databáze: | OpenAIRE |
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