Role of Sigma-1 Receptors in the Regulation of Heart Function: I. The Structure, Localization, and Functional Activity of Sigma-1 Receptors in Cardiomyocytes
| Autor: | I. A. Miroshkina, S. A. Kryzhanovskii |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Physiology
Chemistry Endoplasmic reticulum 05 social sciences Chromosomal translocation 050105 experimental psychology Cell biology Cell membrane 03 medical and health sciences Cell nucleus 0302 clinical medicine medicine.anatomical_structure Physiology (medical) Lipid droplet medicine 0501 psychology and cognitive sciences Receptor Bacterial outer membrane 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | Human Physiology. 47:219-231 |
| ISSN: | 1608-3164 0362-1197 |
| Popis: | The first part of the review examines in detail the structure of sigma-1 (σ1) receptors and the specifics of their intracellular localization and translocation. Literature data indicates that the σ1 receptors that are part of the so-called lipid droplet do not only stationary occur on the outer membrane of the sarcoplasmic reticulum, but they are also translocated to the inner surface of the cell membrane and/or the outer membrane of the cell nucleus. The role that the σ1 receptors play in regulating the function of cardiomyocytes is considered in detail. |
| Databáze: | OpenAIRE |
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