Synthesis of (E)-α,β-Unsaturated CarbonylsviaSilver-Catalyzed Tandem Epoxide Rearrangement/Intermolecular Carbonyl- Heteroalkyne Metathesis

Autor:	Gangguo Zhu, Yan Zhang, Jiayao He, Hui Zhu, Jin Weiwei
Rok vydání:	2016
Předmět:	Tandem 010405 organic chemistry Stereochemistry Intermolecular force Epoxide General Chemistry 010402 general chemistry Metathesis 01 natural sciences 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Functional group Ynol Stereoselectivity
Zdroj:	Advanced Synthesis & Catalysis. 358:3730-3735
ISSN:	1615-4150
Popis:	A regio- and stereoselective method for the synthesis of (E)-α,β-unsaturated carbonyls has been developed via a silver-catalyzed tandem epoxide rearrangement/intermolecular carbonyl-heteroalkyne metathesis. Various heteroalkynes including ynol ethers, ynamides, and thioalkynes work well for this transformation, leading to the production of (E)-α,β-unsaturated esters, amides, and thioesters in moderate to excellent yields with good functional group compatibility. It represents one of the rare examples of regio- and stereoselective intermolecular alkyne-carbonyl metathesis (ACM).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2fd10da8d9f98cf263848b136919177e https://doi.org/10.1002/adsc.201600623 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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