Prognostic factors after resection of locally advanced non-functional pancreatic neuroendocrine neoplasm: an analysis from the German Cancer Registry Group of the Society of German Tumor Centers

Autor: Thaer S. A. Abdalla, Monika Klinkhammer-Schalke, Sylke Ruth Zeissig, Kees Kleihues-van Tol, Kim C. Honselmann, Rüdiger Braun, Louisa Bolm, Hryhoriy Lapshyn, Stanislav Litkevych, Sergii Zemskov, Nehara Begum, Birte Kulemann, Richard Hummel, Ulrich Friedrich Wellner, Tobias Keck, Steffen Deichmann
Rok vydání: 2023
Předmět:
Zdroj: Journal of Cancer Research and Clinical Oncology.
ISSN: 1432-1335
0171-5216
DOI: 10.1007/s00432-023-04785-0
Popis: Objective The available literature regarding outcome after pancreatic resection in locally advanced non-functional pNEN (LA-pNEN) is sparse. Therefore, this study evaluates the current survival outcomes and prognostic factors in after resection of LA-pNEN. Materials and methods This population-based analysis was derived from 17 German cancer registries from 2000 to 2019. Patients with upfront resected non-functional non-metastatic LA-pNEN were included. Results Out of 2776 patients with pNEN, 277 met the inclusion criteria. 137 (45%) of the patients were female. The median age was 63 ± 18 years. Lymph node metastasis was present in 45%. G1, G2 and G3 pNEN were found in 39%, 47% and 14% of the patients, respectively. Resection of LA-pNEN resulted in favorable 3-, 5- and 10-year overall survival of 79%, 74%, and 47%. Positive resection margin was the only potentially modifiable independent prognostic factor for overall survival (HR 1.93, 95% CI 1.71–3.69, p value = 0.046), whereas tumor grade G3 (HR 5.26, 95% CI 2.09–13.25, p value p value = 0.012) were the only independent prognostic factors for disease-free survival. Conclusion Resection of LA-pNEN is feasible and associated with favorable overall survival. G1 LA-pNEN with negative resection margins and absence of lymph node metastasis and lymphangiosis might be considered as cured, while those not fulfilling these criteria might be considered as a high-risk group for disease progression. Herein, negative resection margins represent the only potentially modifiable prognostic factor in LA-pNEN but seem to be influenced by tumor grade.
Databáze: OpenAIRE
Externí odkaz: