Development of Biocompatible Glues for Minimum Invasive Therapy
| Autor: | Tetsuya Tateishi, Hisaki Saito, Masataka Sakane, Sachiro Kakinoki, Tetsushi Taguchi, Naoyuki Ochiai, Masashi Iwasashi |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Materials science
Carbodiimide hydrochloride Mechanical Engineering technology industry and agriculture macromolecular substances Human serum albumin Biocompatible material chemistry.chemical_compound surgical procedures operative chemistry Mechanics of Materials Bonding strength Mouse skin otorhinolaryngologic diseases medicine General Materials Science cardiovascular diseases Fibrin glue GLUE Citric acid Nuclear chemistry medicine.drug Biomedical engineering |
| Zdroj: | Key Engineering Materials. :1339-1342 |
| ISSN: | 1662-9795 |
| DOI: | 10.4028/www.scientific.net/kem.330-332.1339 |
| Popis: | A biocompatible glue consisting of human serum albumin (HSA) and citric acid derivative (CAD), named CAD-A glue was developed. CAD was successfully synthesized by the reaction between citric acid and N-hydroxysuccinimide in the presence of 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride. When the CAD-A glue was applied to the collagenbased casings, it took 7 min to obtain half of maximum bonding strength (760 g/cm2). The bonding strength of this glue to collagen-based casings increased with increasing of HSA concentration.The bonding strength of CAD-A glue increased with increasing CAD concentration up to 200 mM, and then decreased with increasing CAD concentration under the fixed HSA concentration (50 w/w%). The CAD-A glue showed excellent wound closure ability rather than fibrin glue when applied to the mouse skin. These results suggested that this developed glue had both tissue compatibility and bonding strength for use in clinical field. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|