Synthesis and Antiaggregant Activity of 2-[3-Methyl-1-Ethylxanthinyl-8-Thio]Acetic Acid Salts Containing a Thietane Ring

Autor:	D. Z. Murataev, A. V. Samorodov, F. A. Khaliullin, G. A. Timirkhanova, F. Kh. Kamilov, Yu. V. Shabalina
Rok vydání:	2018
Předmět:	Pharmacology Thietane 010405 organic chemistry Thio Nuclear magnetic resonance spectroscopy Ring (chemistry) 01 natural sciences Medicinal chemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Acetic acid chemistry Sodium hydroxide Morpholine Drug Discovery Thioglycolic acid
Zdroj:	Pharmaceutical Chemistry Journal. 52:52-56
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-018-1764-y
Popis:	Reaction of 7-(thietanyl-3)-, 7-(1-oxothietanyl-3)-, and 7-(1,1-dioxothietanyl-3)-8-bromo-3-methyl-1-ethylxanthines with thioglycolic acid produced 2-[3-methyl-1-ethylxanthinyl-8-thio]acetic acids containing a thietane ring with yields of 76 – 93%. Interaction of these acids with bases (sodium hydroxide, morpholine, hexamethyleneimine) produced 2-[3-methyl-1-ethylxanthinyl-8-thio]acetic acid salts containing a thietane ring, with yields of 44 – 96%. The structures of these compounds were confirmed by IR and NMR spectroscopy data. The compounds synthesized here had potentially high antiaggregatory activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2faeee7e8e50012214e71470fe9987e1 https://doi.org/10.1007/s11094-018-1764-y Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.