The increase of bioavailability and antiinflammatory effect of indomethacin included into phospholipid nanoparticles

Autor:	N V Medvedeva, E G Tikhonova, V N Prozorovskiĭ, A V Shironin, T S Zakharova, T I Torkhovskaia, O. M. Ipatova, M A Sanzhakov
Rok vydání:	2011
Předmět:	medicine.drug_class Phospholipid Arthritis Inflammation General Medicine Pharmacology medicine.disease General Biochemistry Genetics and Molecular Biology Anti-inflammatory Bioavailability chemistry.chemical_compound chemistry Phosphatidylcholine Edema medicine medicine.symptom Drug carrier
Zdroj:	Biomeditsinskaya Khimiya. 57:671-676
ISSN:	2310-6905 2310-6972
Popis:	The ultrafine formulation on the base of plant phosphatidylcholine and antiinflammatory remedy indomethacin with nanoparticles less than 50 nm was obtained. Drug bioavailability after its peroral administration to rats was more than 2 fold higher as compared with free indomethacin. Increased antiinflammatory activity of indomethacin in phospholipids nanoparticles as compared with its free form was shown in two models of inflammation - adjuvant arthritis in rats and conconavalin A induced edema in mice. The increased bioavailability of indomethacin after administration of its phospholipid formulation allows to decrease a dose for achievement of therapeutic effect, that reduces risks of occurrence of collateral displays.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2f9287c170ccee2f72ecc12d9f7e587c https://doi.org/10.18097/pbmc20115706671 Zobrazit plný text záznamu