Nifedipine and Methylprednisolone in Facilitating Ureteral Stone Passage: A Randomized, Double-Blind, Placebo-Controlled Study

Autor:	Tiziana Meschi, Loris Borghi, Almerico Novarini, Cristina Quarantelli, Ferdinando Amato, Francesco Mineo, Alfredo Giannini
Rok vydání:	1994
Předmět:	medicine.medical_specialty medicine.drug_class business.industry Urology Placebo-controlled study Antagonist Placebo law.invention Surgery Ureter medicine.anatomical_structure Randomized controlled trial Methylprednisolone Nifedipine law medicine Corticosteroid business medicine.drug
Zdroj:	Journal of Urology. 152:1095-1098
ISSN:	1527-3792 0022-5347
DOI:	10.1016/s0022-5347(17)32511-9
Popis:	Expulsive medical therapy of ureteral stones is not well established. To test the efficacy of a calcium antagonist (nifedipine) associated with a corticosteroid (methylprednisolone) in facilitating ureteral stone passage, we studied 86 patients with a unilateral ureteral radiopaque stone not larger than 15mm. in maximum diameter, confirmed in each case by drop excretory urography. Patients were randomly treated for a maximum of 45 days under double-blind conditions with 16mg. methylprednisolone plus 40mg. nifedipine daily (group 1—13 women and 30 men, mean age 45 ± 14 years, standard deviation) and with 16mg. methylprednisolone plus placebo daily (group 2—18 women and 25 men, mean age 43 ± 14 years). All patients also received 2 l. of low mineral content water daily. The average maximum diameter of the stones was 6.7 ± 3.0mm. in group 1 and 6.8 ± 2.9mm. in group 2 (not significant). Partial ureteral obstruction was present in approximately half of the patients in both groups.Four patients in group...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2f90cf881ffbb1bf38c10dbfafb6fc0b https://doi.org/10.1016/s0022-5347(17)32511-9 Zobrazit plný text záznamu