Effects of Fluorescein Instillation Methods on the Tear Film Lipid Layer
| Autor: | Donald R. Korb, Victor M. Finnemore, Jack V. Greiner, Eleanor A. Bueno, Thomas Glonek, Joan M. Exford, John P. Herman |
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| Rok vydání: | 2002 |
| Předmět: |
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Pathology medicine.medical_specialty business.industry Dry eyes Common denominator medicine.disease medicine.disease_cause eye diseases chemistry.chemical_compound Ophthalmic solutions chemistry Ophthalmology medicine KERATOCONJUNCTIVITIS SICCA sense organs Irritation Fluorescein business Ocular surface |
| Zdroj: | Advances in Experimental Medicine and Biology ISBN: 9781461352082 |
| DOI: | 10.1007/978-1-4615-0717-8_71 |
| Popis: | Tear film stability has been a common denominator among conditions causing irritation of the ocular surface since Holly’s report in 1973.1 Pflugfelder et al.2 noted “An unstable tear film is the hallmark of various dry eye states.” The NEI/Industry Workshop on Clinical Trials in Dry Eyes reported breakup time (BUT) to be the only clinical test available to measure tear film stability.3 The fluorescein BUT (FBUT) test was introduced as corneal wetting time by Norn4 in 1969 and subsequently refined into the BUT test by Lemp5 in 1973. Although a reduced BUT is considered a global criterion of dry eye,3 it is criticized as not accurate or reproducible, and is not universally accepted.6–9 Inherently, the FBUT test is invasive, thus compromising its reproducibility.7,9 |
| Databáze: | OpenAIRE |
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