Trace level electrochemical detection of mesalazine in human urine sample using poly (N-Vinyl)-2-Pyrrolidone capped Bi-EDTA complex sheets incorporated with ultrasonically exfoliated graphene oxide
| Autor: | Sea-Fue Wang, Narasimha Murthy Umesh, Antolin Jesila Jesu Amalraj |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Graphene General Chemical Engineering technology industry and agriculture Oxide 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Electrochemistry 01 natural sciences 0104 chemical sciences law.invention Electrochemical gas sensor chemistry.chemical_compound Linear range chemistry law Electrode 2-Pyrrolidone 0210 nano-technology Selectivity Nuclear chemistry |
| Zdroj: | Journal of the Taiwan Institute of Chemical Engineers. 122:67-77 |
| ISSN: | 1876-1070 |
| Popis: | Trace level detection of drugs and hazardous analytes is more critical in electrochemical sensor. In this work, a simple sonochemical-assisted synthesis of Bismuth-EDTA complex/GO flakes was achieved and was developed to analyze mesalazine (MSA) sensing. The 3D hollow bricks were obtained for the Bi-EDTA complex without PVP. Surprisingly, PVP influenced the formation of broken glass-like structured for PVP with Bi-EDTA complex. Bi-EDTA complex modified GCE was developed to determine the role of PVP and its activity in electrochemical sensors. The results obtained by modifying the electrode Bi-EDTA complex with PVP showed good electrochemical performance compared to bare and other controls like GO and Bi-EDTA complex without PVP. The synergetic effect and high electroactive sites of Bi-EDTA complex/GO modified sensor implied low LOD (0.55 nM) and wide linear range from 0.005–585 µM. Furthermore, Bi-EDTA complex/GO showed an excellent selectivity in sensing MSA. Moreover, the Bi-EDTA complex exhibits advantages such as good stability, reproducibility, and repeatability. The modified Bi-EDTA complex/GCE sensor has been practically done to determine trace levels of MSA in human urine samples containing mesalamine tablets with satisfactory results. |
| Databáze: | OpenAIRE |
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