Studies of the Solubility of Rutin from Solid Dispersions

Autor:	I. V. Koval’skii, I. I. Krasnyuk, O. I. Nikulina, A. V. Belyatskaya, Yu. Ya. Kharitonov, N. B. Fel’dman, S. V. Lutsenko, V. V. Grikh
Rok vydání:	2014
Předmět:	Pharmacology chemistry.chemical_classification Chromatography Polyvinylpyrrolidone Chemistry Polymer Polyethylene glycol Rutin chemistry.chemical_compound Crystallinity Drug Discovery medicine Solubility Dissolution medicine.drug Solid solution
Zdroj:	Pharmaceutical Chemistry Journal. 47:612-615
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-014-1020-z
Popis:	The effects of solid dispersions (SD) on the solubility of rutin were studied. Rutin and its SD with polyethylene glycol 1500 and polyvinylpyrrolidone 10000 were studied. Preparation of SD increased the solubility and rate of dissolution of the active substance. The solubility of rutin from SD increased by a factor of 52. The physicochemical methods used here suggested that improvements in rutin release from SD result from decreases in crystallinity and formation of solid solutions of drug in polymer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2f831a811daf9bdf9913643f75c15944 https://doi.org/10.1007/s11094-014-1020-z Zobrazit plný text záznamu Plný text ve formátu PDF