Triphasic locomotor response of a plant-parasitic nematode to avermectin: inhibition by the GABA antagonists bicuculline and picrotoxin
| Autor: | A. J. Birtle, I. T. J. Roberts, Denis J. Wright |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Neuromuscular transmission Oxamyl Pharmacology GABA receptor antagonist Biology Bicuculline biology.organism_classification chemistry.chemical_compound Infectious Diseases Endocrinology chemistry Acetylcholinesterase inhibitor Internal medicine medicine Meloidogyne incognita Animal Science and Zoology Parasitology Avermectin Picrotoxin medicine.drug |
| Zdroj: | Parasitology. 88:375-382 |
| ISSN: | 1469-8161 0031-1820 |
| Popis: | SUMMARYThe response of the plant parasitic nematode, Meloidogyne incognita (J2 stage) to avermectin B2a-23-one is triphasic, comprising an initial loss of locomotor activity where the juveniles remain sensitive to touch, a recovery phase and a final loss of activity where the juveniles are relatively insensitive to touch. In contrast, the acetylcholinesterase inhibitor, oxamyl, causes initial hyperactivity of juveniles followed by a progressive decline in movement. The addition of bicuculline and to a lesser extent picrotoxin, both antagonists of γ-aminobutyric acid (GABA), blocks the action of avermectin on M. incognita. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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