Reproducible effects of intravenously administered fish oil in acute relapsing psoriasis

Autor:	Ewald Schlotzer, C. Papavassilis, Peter Mayser, F. Grimminger, Werner Seeger
Rok vydání:	1996
Předmět:	chemistry.chemical_classification medicine.medical_specialty Leukotriene Exacerbation business.industry Eicosanoid metabolism Fatty acid Dermatology medicine.disease Fish oil Eicosapentaenoic acid Gastroenterology Surgery chemistry Docosahexaenoic acid Internal medicine Psoriasis medicine business
Zdroj:	Journal of Dermatological Treatment. 7:211-214
ISSN:	1471-1753 0954-6634
DOI:	10.3109/09546639609089550
Popis:	In several studies, dietary fish oil has been found to be beneficial in psoriasis, although the results have been controversial. To overcome the slow kinetics and limited availability of oral supplementation, a patient with acute relapsing psoriasis received an ω-3 fatty acid-based lipid emulsion (100 ml/day containing 2.1 g eicosapentaenoic acid (EPA) and 2.1 g docosahexaenoic acid) for 10 days. Clinical symptoms were assessed using the PASI. The PASI score dropped from 18.4 to 4.2. In addition leukotriene generation of ionophore-stimulated neutrophils showed a more than tenfold increase in EPA-derived lipoxygenase product formation. Because of a renewed exacerbation 1 year later, a second trial was started with double the previous dose over a period of 15 days. Probably because of a worse clinical condition, the patient responded more slowly than during the first trial, and the increase in EPA-derived metabolites was more retarded. Modulation of eicosanoid metabolism by intravenous ω-3 fatty acid supple...
Databáze:	OpenAIRE
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