Water-soluble nonstoichiometric polyelectrolyte complexes of modified chitosan

Autor:	Vladimir A. Izumrudov, I. F. Volkova, E. S. Grigoryan, M. Yu. Gorshkova
Rok vydání:	2011
Předmět:	chemistry.chemical_classification Aqueous solution Polymers and Plastics Polymer Degree of polymerization Alkylation Polyelectrolyte Chitosan chemistry.chemical_compound chemistry Ionic strength Polymer chemistry Materials Chemistry Solubility
Zdroj:	Polymer Science Series A. 53:281-288
ISSN:	1555-6107 0965-545X
DOI:	10.1134/s0965545x11040043
Popis:	A modified polysaccharide that, in each deacetylated unit, carries a functional secondary amino group and a quaternized amino group that provides a positive charge and solubility to the polymer throughout the pH range is prepared by the alkylation of primary amino groups of chitosan with glycidyltrimethylammonium chloride. The mixing of modified chitosan solutions with solutions of polystyrenesulfonate or polymethacrylate anions in neutral solutions gives rise to negatively charged nonstoichiometric polyelectrolyte complexes soluble and stable under physiological conditions. The effects of pH, ionic strength, the degree of polymerization, the nature of the lyophilizing polyanion, and the charge-to-charge ratio of components on the boundaries of existence of soluble complexes are ascertained. The collected experimental data may serve as a basis for designing biocompatible and biodegradable means useful for the delivery of genetic material and drugs to living cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2f74d24bc597aa697cbe47227b65b149 https://doi.org/10.1134/s0965545x11040043 Zobrazit plný text záznamu Full text from SpringerLink