Involvement of nitric oxide in the mechanism of adrenergic responses of systemic circulation
| Autor: | L. I. Osadchii, T. V. Balueva, I. V. Sergeev |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Agonist
medicine.medical_specialty medicine.drug_class Adrenergic Stimulation Vasodilation Biology General Biochemistry Genetics and Molecular Biology Nitric oxide chemistry.chemical_compound medicine.anatomical_structure Mean blood pressure Endocrinology chemistry Internal medicine medicine Vascular resistance General Agricultural and Biological Sciences Phenylephrine medicine.drug |
| Zdroj: | Biology Bulletin. 34:36-40 |
| ISSN: | 1608-3059 1062-3590 |
| DOI: | 10.1134/s1062359007010050 |
| Popis: | Increased pressor response to the infusion of α1-adrenoceptor agonist phenylephrine was observed in conditions of inhibited NO synthesis: the mean blood pressure increased from 33.7 to 41.1% and the total peripheral resistance increased from 6.8 to 22.0%. The effect of vasodilation induced by NO secretion in the vascular endothelium after the stimulation by α1-adrenoceptors on the degree of pressor changes and changes in the total peripheral resistance is proposed. |
| Databáze: | OpenAIRE |
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