Emerging Roles of NAD + and Its Metabolites in Cell SignalingA report on the NAD2008 symposium, Hamburg, Germany, 14 to 17 September 2008
| Autor: | Andreas H. Guse, Friedrich Koch-Nolte, Friedrich Haag, Frances E. Lund, Mathias Ziegler |
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| Rok vydání: | 2009 |
| Předmět: |
chemistry.chemical_classification
Nicotinic acid adenine dinucleotide phosphate biology Cell Biology Nicotinamide adenine dinucleotide Biochemistry Cofactor chemistry.chemical_compound Enzyme chemistry Second messenger system biology.protein NAD+ kinase Signal transduction Molecular Biology Intracellular |
| Zdroj: | Science Signaling. 2 |
| ISSN: | 1937-9145 1945-0877 |
| Popis: | Nicotinamide adenine dinucleotide (NAD(+)) is the universal currency of energy metabolism and electron transfer. Recent studies indicate that apart from its role as a coenzyme, NAD(+) and its metabolites also function in cell signaling pathways; for example, they are substrates for nucleotide-metabolizing enzymes and ligands for extra- and intracellular receptors and ion channels. Moreover, the NAD(+) and NAD(+) phosphate metabolites adenosine 5'-diphosphoribose (ADP-ribose), cyclic ADP-ribose, and nicotinic acid adenine dinucleotide phosphate (NAADP) have emerged as key second messengers in Ca(2+) signaling. A symposium in Hamburg, Germany, brought together 120 researchers from various fields, who were all engaged in the molecular characterization of the key players of NAD(+) signaling (www.NAD2008.de). |
| Databáze: | OpenAIRE |
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