Neoadjuvant Chemotherapy is Associated with Lower Lymph Node Counts in Colon Cancer
| Autor: | Traci L. Hedrick, Taryn E. Hassinger, Alex D. Michaels, Puja M. Shah, Florence E. Turrentine, Matthew G. Mullen, Charles M. Friel |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Chemotherapy business.industry Colorectal cancer medicine.medical_treatment General Medicine medicine.disease 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis medicine 030211 gastroenterology & hepatology Lymphadenectomy Radiology Lymph Risk factor business Lymph node Neoadjuvant therapy Colectomy |
| Zdroj: | The American Surgeon. 84:996-1001 |
| ISSN: | 1555-9823 0003-1348 |
| Popis: | Adequate lymphadenectomy is associated with improved survival in patients who undergo oncologic resection of colorectal cancer and has been identified as a quality metric. Neoadjuvant chemotherapy has been found to be associated with collection of 12 lymph nodes. Of 9077 patients with a diagnosis of colon cancer who underwent colectomy, a minimum of 12 lymph nodes was harvested in 7897 (87%). Significant factors independently associated with inadequate lymphadenectomy included preoperative chemotherapy, emergent surgery, and T1 tumors (all P < 0.05). A large majority of patients who undergo colectomy for colon cancer have at least 12 lymph nodes collected. Preoperative chemotherapy is a major risk factor for inadequate lymph node retrieval. Recognition of factors associated with inadequate lymphadenectomy may improve colectomy lymph node yield and survival in patients with colon cancer. |
| Databáze: | OpenAIRE |
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