Radiomics on radiography predicts giant cell tumor histologic response to denosumab
| Autor: | Darcy A. Kerr, Radka Stoyanova, Juan Pretell-Mazzini, Breelyn A. Wilky, Ty K. Subhawong, Sofia Danilova, Yu Cherng Chang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
030203 arthritis & rheumatology
medicine.medical_specialty business.industry Radiography Histological response medicine.disease 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Denosumab Radiomics Giant cell Orthopedic surgery medicine Radiology Nuclear Medicine and imaging Radiology Giant Cell Tumors business Giant-cell tumor of bone medicine.drug |
| Zdroj: | Skeletal Radiology. 50:1881-1887 |
| ISSN: | 1432-2161 0364-2348 |
| Popis: | Denosumab is an established targeted systemic therapy for treatment of giant cell tumor of bone (GCTB). We sought to determine whether treatment response could be quantified from radiomics analysis of radiographs taken longitudinally during treatment. Pre- and post-treatment radiographs of 10 GCTB tumors from 10 patients demonstrating histologic response after treatment with denosumab were analyzed. Intensity- and texture-based radiomics features for each manually segmented tumor were calculated. Radiomics features were compared pre- and post-treatment in tumors. Mean intensity (p = 0.033) significantly increased while skewness (p = 0.028) significantly decreased after treatment. Post-treatment increases in fractal dimensions (p = 0.057) and abundance (p = 0.065) approached significance. A potential linear correlation in mean (p = 0.005; ΔMean = 0.022 * duration − 0.026) with treatment duration was observed. Radiomics analysis of plain radiographs quantifies time-dependent matrix mineralization and trabecular reconstitution that mark positive response of giant cell tumors of bone to denosumab. |
| Databáze: | OpenAIRE |
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