| Autor: |
Carlos Prete Junior, Lewis Buss, Tassila Salomon, Marcio Oikawa, Rafael Pereira, Isabel Moura, Lucas Delerino, Manoel Barral-Netto, Natalia Tavares, Rafael Franca, Viviane Boaventura, Fabio Miyajima, Alfredo Medrone Junior, Cesar de Almeida Neto, Nanci Salles, Suzete Ferreira, Karine Fladzinski, Luana de Souza, Luciane Schier, Patricia Inoue, Nelson Fraiji, Lilyane Xabregas, Myuki Crispim, Fernando Araujo, Luciana Carlos, Veridiana Pessoa, Maisa Ribeiro, Rosenvaldo de Souza, Anna Cavalcante, Maria Valença, Maria da Silva, Esther Lopes, Luiz Amorim, Sheila Mateos, Gabrielle Nunes, Samara Santos, Alexander Silva-Junior, Michael Busch, Marcia Castro, Christopher Dye, Oliver Ratmann, Nuno Faria, Charles Whittaker, Vitor Nascimento, Ester Sabino |
| Rok vydání: |
2022 |
| Popis: |
There are large differences in the shape and size of regional SARS-CoV-2 epidemics in Brazil. Here we tested monthly blood donation samples for IgG antibodies from March 2020 to March 2021 in eight of Brazil’s most populous cities. There was large variation in the inferred attack rate adjusted for seroreversion across cities, and seroprevalence was consistently smaller in women and donors older than 55 years. The age-specific infection fatality rate differed between cities and consistently increased with age. The infection hospitalisation rate (IHR) increased significantly during the gamma-dominated second wave in Manaus, suggesting increased morbidity of the Gamma VOC compared to previous variants circulating in Manaus. The higher disease penetrance associated with the health system’s collapse increased the overall IFR by a minimum factor of 2.91 (95% CrI 2.43–3.53). These results demonstrate large heterogeneity in epidemic spread and highlight the utility of blood donor serosurveillance to monitor SARS-CoV-2 epidemics. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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