Synthesis and in vitro anticancer evaluation of novel flavonoid-based amide derivatives as regulators of the PI3K/AKT signal pathway for TNBC treatment

Autor: Dailong Zha, Yuanzhi Li, Yingqi Luo, Yingfan Liu, Zehong Lin, Chujie Lin, Siyue Chen, Jiangping Wu, Lihong Yu, Shaobin Chen, Peiquan Zhang, Wenhao Wu, Chao Zhang
Rok vydání: 2022
Předmět:
Zdroj: RSC Medicinal Chemistry. 13:1082-1099
ISSN: 2632-8682
DOI: 10.1039/d2md00148a
Popis: Flavonoid-based amide 7t possesses excellent cytotoxicity against MDA-MB-231 cells and its antitumor activity is achieved by affecting the PI3K/AKT pathway with inducing apoptosis.
Databáze: OpenAIRE