Autor:	Naoki Watanabe, Hiroyuki Hisai, Masayoshi Horimoto, Kazuhiro Morii, Yoshiro Niitsu, Takashi Kuya, Sumio Sakamaki, Katsuhisa Kogawa
Rok vydání:	1995
Předmět:	biology business.industry medicine.medical_treatment T cell CD3 Hematology T lymphocyte medicine.disease Lymphoma Cytokine medicine.anatomical_structure Polyclonal antibodies hemic and lymphatic diseases Immunology medicine biology.protein Antibody B-cell lymphoma business
Zdroj:	International Journal of Hematology. 62:253
ISSN:	0925-5710
DOI:	10.1016/0925-5710(95)00413-0
Popis:	The mechanism of abnormal immunoglobulin production in non-Hodgkin's lymphoma is still poorly understood. We report a case of B-cell type non-Hodgkin's lymphoma associated with marked elevated polyclonal hyper-gammaglobulinemia (serum IgG was 7598 mg/dl; IgM, 455 mg/dl). We conducted a mixed lymphocyte culture test using peripheral lymphocytes obtained from the patient and a healthy volunteer. After co-culture with the patient's CD3+ cells, not only the patient's CD3- cells but also control CD3- cells produced greater amounts of IgG and IgM. Elevated IL-6 was also detected from the patient's CD3+ cells. This strongly suggests that B-lymphoma cells stimulate CD3+ cells to produce IL-6 and hence activate normal CD3- cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2f5b4c4202c68b66983d370ecd88ee92 https://doi.org/10.1016/0925-5710(95)00413-0 Zobrazit plný text záznamu