Posttransplantation Diabetes
| Autor: | Patricia J. Erwin, Jorge A. Velosa, Victor M. Montori, Ananda Basu, Yogish C. Kudva, Sherine E. Gabriel |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Advanced and Specialized Nursing
Research design Pediatrics medicine.medical_specialty business.industry Endocrinology Diabetes and Metabolism Incidence (epidemiology) MEDLINE Cochrane Library Surgery law.invention Transplantation Randomized controlled trial law Internal Medicine medicine Cumulative incidence Risk factor business |
| Zdroj: | Diabetes Care. 25:583-592 |
| ISSN: | 1935-5548 0149-5992 |
| Popis: | OBJECTIVES— To systematically review the incidence of posttransplantation diabetes (PTD), risk factors for its development, prognostic implications, and optimal management. RESEARCH DESIGN AND METHODS— We searched databases (MEDLINE, EMBASE, the Cochrane Library, and others) from inception to September 2000, reviewed bibliographies in reports retrieved, contacted transplantation experts, and reviewed specialty journals. Two reviewers independently determined report inclusion (original studies, in all languages, of PTD in adults with no history of diabetes before transplantation), assessed study methods, and extracted data using a standardized form. Meta-regression was used to explain between-study differences in incidence. RESULTS— Nineteen studies with 3,611 patients were included. The 12-month cumulative incidence of PTD is lower ( CONCLUSIONS— Physicians should consider modification of immunosuppressive regimens to decrease the risk of PTD in high-risk transplant recipients. Randomized trials are needed to evaluate the use of oral glucose-lowering agents in transplant recipients, paying particular attention to interactions with immunosuppressive drugs. |
| Databáze: | OpenAIRE |
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