Untersuchung der Wirksamkeit von systemischen bzw. topischen Kortikoiden und Vitamin B bei Riechstörungen
| Autor: | Tino Just, Ö Göktas, Karl-Bernd Hüttenbrink, Stefan Heilmann, Thomas Hummel, Bettina Hauswald |
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| Rok vydání: | 2004 |
| Předmět: |
Olfactory system
medicine.medical_specialty business.industry medicine.medical_treatment Anosmia Mometasone furoate Olfaction Gastroenterology Endocrinology medicine.anatomical_structure Otorhinolaryngology Nasal spray Internal medicine medicine Systemic administration Nasal administration medicine.symptom business medicine.drug Respiratory tract |
| Zdroj: | Laryngo-Rhino-Otologie. 83:729-734 |
| ISSN: | 1438-8685 0935-8943 |
| Popis: | BACKGROUND Aim of the present, unblinded, multicentric, open trial was to compare effects of 3 treatments in patients with olfactory dysfunction. METHODS Treatments included administration of systemic corticosteroids (oral prednisolone), local corticosteroids (mometasone nasal spray), and systemic vitamin B, respectively. A total of 192 patients participated (95 women, 97 men; mean age 56 years). Duration of the smell loss ranged from 1 to 288 months (average 45 months). Olfactory dysfunction was due to infections of the upper respiratory tract (n = 72), sinunasal disease (n = 19), and posttraumatic olfactory loss (n = 10); the largest portion was classified as idiopathic (n = 85); other causes were rare (n = 6). RESULTS Following systemic administration of corticosteroids improvement of olfactory function was observed (p < 0.001). Similarly, improvement of the sense of smell was found 2 (p = 0.03) and 6 months (p = 0.001) after local administration of mometasone, respectively. In contrast, after administration of vitamin B no significant change of olfactory function was seen after 2 months, while improvement was present after 6 months (p = 0.001). Duration of olfactory dysfunction had no effect on changes of smell function. CONCLUSIONS These results indicate that improvement of olfactory function is found in olfactory dysfunction of different causes. Adequately controlled, blinded studies are needed to further explore potential effects of the various treatments. |
| Databáze: | OpenAIRE |
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