Synthesis of Fluorine-Containing Derivatives of 5-Arylisoxazoles and 4,5-Dichlorothiazole

Autor:	R. M. Zolotar, E. A. Dikusar, I. B. Rozenzveig, A. V. Kletskov, Galina G. Levkovskaya, Vladimir I. Potkin, Sergey K. Petkevich, P. V. Kurman
Rok vydání:	2018
Předmět:	Reaction conditions Isothiazole 010405 organic chemistry Phenolic aldehyde Condensation Fluorine containing General Chemistry Alkylation 010402 general chemistry 01 natural sciences 0104 chemical sciences Acylation chemistry.chemical_compound chemistry Organic chemistry Isoxazole
Zdroj:	Russian Journal of General Chemistry. 88:234-240
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363218020081
Popis:	Alkylation of fluorophenols and phenolic aldehydes with 5-phenyl(p-tolyl)-3-chloromethylisoxazole under the Williamson reaction conditions afforded the corresponding ethers. Condensation of the resulting phenolic aldehyde derivatives and 5-phenyl(p-tolyl)isoxazole-3-carbaldehydes with p-fluoroaniline resulted in fluorine-containing azomethines. Acylation of fluorinated amines with 5-(p-tolyl)isoxazole- and 4,5- dichloroisothiazole-3-carbonyl chlorides gave rise to fluorinated amides bearing isoxazole and isothiazole fragments, representatives of which showed a synergistic effect in compositions with insecticides.
Databáze:	OpenAIRE
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