Mechanisms of the Cytotoxic Action of Organotin Compounds

Autor:	Elena R. Milaeva, I. M. Kotieva, M. A. Dodokhova, D.B. Shpakovsky, T.A. Antonenko, E. V. Gantsgorn, Ekaterina Fedorovna Komarova, M. S. Alkhuseyn-Kulyaginova, A. V. Safronenko
Rok vydání:	2021
Předmět:	Action (philosophy) 010405 organic chemistry Chemistry Cytotoxic T cell Pharmacology 010402 general chemistry 01 natural sciences 0104 chemical sciences
Zdroj:	Journal Biomed. 17:88-99
ISSN:	2713-0428 2074-5982
DOI:	10.33647/2074-5982-17-2-88-99
Popis:	This review analyzed the literature data on the in vitro preclinical study of the cytotoxic properties of organotin compounds, as well as the main mechanisms of their action. The latter consist in interacting with SH groups of proteins, initiating oxidative stress, binding to DNA, interacting with receptors, as well as activate apoptosis by increasing the expression of caspases, proapoptotic proteins, and decreasing antiapoptotic proteins. Organotin compounds, depending on the donor ligand, exhibit specifi c cytotoxicity towards certain tumor cell lines. The high cytotoxic potential indicates the possibility of further development in vivo and research of organotin compounds as candidates for the creation of drugs for anticancer and antimetastatic therapy.
Databáze:	OpenAIRE
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