Ethanolic Extract ofVaccinium corymbosumAlleviates Muscle Fatigue in Mice
| Autor: | Shintae Kim, Jinseop Shin, Jeongmin Lee, Sang-In Shim, Jin Woong Chung, Jeongjin Park, Ok-Kyung Kim, Yanghee You, Kyungmi Kim, Woojin Jun |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Nutrition and Dietetics Muscle fatigue Coenzyme A Medicine (miscellaneous) Fatty acid TFAM Peroxisome chemistry.chemical_compound Endocrinology chemistry Mitochondrial biogenesis Endurance training Internal medicine medicine Carnitine medicine.drug |
| Zdroj: | Journal of Medicinal Food. 23:1225-1229 |
| ISSN: | 1557-7600 1096-620X |
| Popis: | The aim of this study was to evaluate the effects of ethanol extracts of Vaccinium corymbosum (VCE) on exercise-induced fatigue in mice. Mice were randomly divided into three groups; nonexercise control group (CON), exercise control group (Ex-CON), and exercise and VCE supplementation group (Ex-VCE). Compared with Ex-CON, Ex-VCE showed increased endurance exercise capacity on day 21. In Ex-VCE mice, the accumulation of lactate was inhibited and the consumption of fatty acids was enhanced, indicating the delay of muscle fatigue. In addition, VCE supplementation elevated mRNA expression levels of mitochondrial biogenesis-associated genes such as peroxisome proliferator-activated receptor-1γ coactivator 1α (PGC-1α), nuclear respiratory factor (NRF), and mitochondrial transcription factor A (Tfam) and fatty acid β-oxidation-associated genes such as carnitine palmitoyltransferase-1 (CPT-1), β-hydroxyacyl coenzyme A dehydrogenase (β-HAD), and peroxisome proliferator-activated receptor-δ (PPAR-δ). These results suggest that VCE can potentially prevent muscle fatigue by enhancing mitochondrial biogenesis and fatty acid β-oxidation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|