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Viruses as a whole are important pathogens. They have also been found to have a close association with certain human malignancies. Five types of herpesviruses were identified to be the causative agents in human diseases. They are herpes simplex virus (HSV) type 1, HSV-2, cytomegalovirus (CMV), Epstein Barr virus (EBV) and varicella zoster virus (VZV). These are DNA viruses capable of inducing biochemical changes in infected cells, which in most cases are triggered by virus induced or coded enzymes or proteins (Nahmias et al., 1981; Roizman, 1983). Several enzymes involved in DNA synthesis are known to be specified by some or all types of herpesvirus. A summary of these identified enzymes and the primary reactions they catalyze (Lemaster & Roizman, 1980; Blue & Stobbs, 1981; Cheng et al., 1982) is presented in Table 1. |
