STUDY OF SPECIFIC PHARMACOLOGICAL ACTIVITY OF SODIUM SALT (4-О-Β-GLUCOPYRANOSYLOXY)-BENZOIC ACID

Autor:	Udut Vladimir, Ivanov Alex, Murashko Tatyana, Bondarev Alex, Smirnov Ivan
Rok vydání:	2016
Předmět:	Drug Gastrointestinal tract Peptic medicine.medical_treatment media_common.quotation_subject Analgesic General Engineering Inflammation Biological activity Pharmacology chemistry.chemical_compound chemistry medicine medicine.symptom Diuretic Benzoic acid media_common
Zdroj:	Jurnal Teknologi. 78
ISSN:	2180-3722 0127-9696
DOI:	10.11113/jt.v78.9047
Popis:	Chronic inflammatory diseases of various genesis are prevalent today. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat pain and inflammation, but their long-term use is associated with complications in the gastrointestinal tract, including peptic ulcers. We synthesized a molecule of sodium salt (4-О-β-glucopyranosyloxy)-benzoic acid. This substance has diuretic and anti-inflammatory activities. It should be noted that most of NSAIDs has analgesic effect. In this connection, the aim of this study was to evaluate the analgesic activity of sodium salt (4-О-β-glucopyranosyloxy)-benzoic acid. We studied analgesic effect in the test “acetic writhing”. Sodium salt (4-О-β-glucopyranosyloxy)-benzoic acid significantly reduces the number of writhing by 14 units during the experiment, as an alternative criterion percent of animals with analgesia was 42.6%. Thus, in the test "acetic writhing" revealed the presence of the analgesic activity have developed drug average severity.
Databáze:	OpenAIRE
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