Catalytic asymmetric hydrogenation to access spiroindane dimethyl acetic acid

Autor:	C. Scott Shultz, Peter H. Dobbelaar, Ravi P. Nargund, Ronsar Eid, Zhong Lai, Zhixiong Ye, Shuwen He
Rok vydání:	2011
Předmět:	Organic Chemistry Asymmetric hydrogenation Enantioselective synthesis chemistry.chemical_element Biochemistry Catalysis Ruthenium Acetic acid chemistry.chemical_compound chemistry Yield (chemistry) Drug Discovery Acetone Organic chemistry Enantiomer
Zdroj:	Tetrahedron Letters. 52:3621-3624
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2011.05.029
Popis:	Asymmetric hydrogenation of achiral spiroindene dimethyl acetic acid 2 with 4% of Ru(II)-Mandyphos in acetone produced (S)-spiroindane dimethyl acetic acid 1 in 86% isolated yield and 96.8:3.2 enantiomeric ratio.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::2f378d6ca0977a2dd3fcbfdc6f4911cb https://doi.org/10.1016/j.tetlet.2011.05.029 Zobrazit plný text záznamu Full Text from ScienceDirect