Molecular Evolution of Hepatitis B Virus Genotype F in Latin America

Autor: Vagner Ricardo Lunge, Jonas Michel Wolf, Daniel Simon, Vagner Reinaldo Zingalli Bueno Pereira, Thiago Kastell Mazeto
Rok vydání: 2021
Předmět:
DOI: 10.21203/rs.3.rs-875996/v1
Popis: Hepatitis B virus (HBV) genotype F evolution is not completely understood in Latin America. This study aims to evaluate the molecular evolution of HBV-F in Latin America by comparing 224 whole-genome sequences. Bayesian coalescent analysis was performed to estimate the time to the most recent common ancestor. Four main clades were formed dated back between 1245 and 1730. Also, four subclades were identified dated back between 1705 and 1801. HBV-F overall effective population size grew in the 18th century and showed an initial circulation of HBV-F from Venezuela to other countries from Latin America.
Databáze: OpenAIRE