The efficacy of preventive methods and their combinations in the preterm birth prevention
| Autor: | I. V. Lakhno, O. V. Grishchenko, S. V. Korovai |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | PROBLEMS OF UNINTERRUPTED MEDICAL TRAINING AND SCIENCE. 42:18-21 |
| ISSN: | 2664-5238 2308-3220 |
| DOI: | 10.31071/promedosvity2021.02.018 |
| Popis: | Prediction and prevention of premature birth is a significant problem of modern obstetrics. The use of ultrasound cervicometry and the index of placental angiogenesis for the prediction of premature birth is promising. The aim of the study was to investigate the effectiveness of cerclage, pessary, intravaginal progesterone or their combinations in the prevention of premature birth. A total of 292 pregnant women were examined. They were divided into several groups according to the results of the detection of cervical length and the level of the ratio between placental growth factor (PlGF) and fms-like tyrosine kinase (sFlt-1). Group I included women with a negative screening’ resuls. Other groups included women with a «short» cervix and disturbed placental angiogenesis. In group II, women with cervical cerlage were observed. In group III — used a pessary; Group IV — vaginal progesterone; V — cobined use of cerclage and pessary; and in VI — use of cerclage and vaginal progesterone. The pregnancy was completed at term in 159 patients, and 133 women had preterm delivery. Among patients who had positive miscarriage screening results, the use of preventive measures or combinations resulted in fairly equal results. However, the use of progesterone and cervical cerclage has shown the best efficacy. Some limitations in this study were the small sample size and the lack of information on the use of anticoagulants, disaggregants and tocolytics in the examined women. |
| Databáze: | OpenAIRE |
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