Rapid progressive anti-GBM glomerulonephritis with multiple auto-antibodies
| Autor: | Teresa Valentina Ranalli, David Micarelli, Sandro Feriozzi, Angela Solazzo, Francesca Moccia, Anna Rita Taddei |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Thrombotic microangiopathy medicine.diagnostic_test Anti-nuclear antibody business.industry medicine.medical_treatment Autoantibody Glomerulonephritis urologic and male genital diseases medicine.disease Nephrology medicine Rapidly progressive glomerulonephritis Renal biopsy Hemodialysis Fibrinoid necrosis business |
| Zdroj: | Journal of Nephropathology. 9:e30-e30 |
| ISSN: | 2251-8819 2251-8363 |
| Popis: | Rapidly progressive glomerulonephritis (RPGN) is a clinical syndrome manifested by progressive loss of renal function in a short period. At renal biopsy, it is characterized by crescent formation. RPGN may be associated with the presence of circulating antibodies. We report a case of type IV RPGN [ANCA and Anti–glomerular basement membrane (anti-GBM) antibody disease], a severe disease causing a difficult to treat picture. Our case was complicated by severe thrombocytopenia due to the use of heparin and later on by thrombotic microangiopathy. These events occurred rapidly, making the clinical framing and management decisions very hard. |
| Databáze: | OpenAIRE |
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