Diagnostic utility of PET/CT with 18F-DOPA and 18F-FDG in persistent or recurrent medullary thyroid carcinoma: the importance of calcitonin and carcinoembryonic antigen cutoff
| Autor: | Antonio Jesús Martínez-Ortega, Ana R. Romero-Lluch, Raquel Guerrero-Vázquez, Juan Ignacio Cuenca-Cuenca, Juan Luis Tirado-Hospital, I. Borrego-Dorado, Elena Navarro-González |
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| Rok vydání: | 2017 |
| Předmět: |
Fluorodeoxyglucose
PET-CT medicine.medical_specialty medicine.diagnostic_test biology business.industry Thyroid 030209 endocrinology & metabolism General Medicine 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Isotopes of gallium Carcinoembryonic antigen Calcitonin Positron emission tomography medicine biology.protein Radiology Nuclear Medicine and imaging Radiology business Nuclear medicine Emission computed tomography medicine.drug |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging. 44:2004-2013 |
| ISSN: | 1619-7089 1619-7070 |
| Popis: | This study sought to evaluate and compare the utility of 18-F-fluorodihydroxyphenylalanine (18F-DOPA) and 18-F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) for identification of lesions in patients with recurrent medullary thyroid carcinoma (MTC). In addition, we analyzed the correlation between the calcitonin (Ct), carcinoembryonic antigen (CEA) levels, each doubling time (DT), and PET positivity. We evaluated the reliability of the 150 pg/mL Ct cutoff set by the American Thyroid Association guidelines for further imaging (including 18F-DOPA PET/CT). We prospectively recruited 18 patients with recurrent MTC, identified by elevation of Ct or CEA. Each patient underwent a 18F-FDG PET/CT and a 18F-DOPA PET/CT. Abnormal uptakes were detected with 18F-DOPA (n=12) and 18F-FDG (n=9), (sensitivity of 66.7% vs. 50%; p |
| Databáze: | OpenAIRE |
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