Hematological Markers of In Vivo Toxicity
| Autor: | Njagi Enm, Arika Wm, Michael N Musila, Mathew Piero Ngugi, Nyamai Dw |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.diagnostic_test
business.industry Anemia Metabolite Disease Hematocrit Pharmacology Omics medicine.disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry 030220 oncology & carcinogenesis Toxicity Medicine 030212 general & internal medicine Animal studies business Adverse effect |
| Zdroj: | Journal of Hematology & Thromboembolic Diseases. |
| ISSN: | 2329-8790 |
| DOI: | 10.4172/2329-8790.1000236 |
| Popis: | In modern medical practice, toxicity studies are essential in assessment of safety of extracts or drugs used in clinical medicine. The interaction of the toxin or its metabolite with cellular constituents may bring about significant changes in hematological parameters. These alterations may be rapid or slow and often cause a change in structure and function of the affected tissues. In clinical laboratory setting these blood indices are assayed for the purpose of diagnosis, treatment or prevention of disease, and for greater understanding of the disease process. Therefore, assessment of hematological indices can be diagnostic of adverse effects of foreign compounds on the blood constituents since such hematological alterations have higher predictive value for human toxicity when the data are interpreted from animal studies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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