Opsoclonus as a dominant sign in primary Sjögren’s syndrome
| Autor: | D. Lubec, W. Müllbacher, B. Mamoli, Josef Finsterer, V. Weiler |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Pathology
medicine.medical_specialty Ataxia Nerve biopsy medicine.diagnostic_test biology business.industry Opsoclonus medicine.disease biology.organism_classification eye diseases stomatognathic diseases Ophthalmology Dysarthria stomatognathic system Vertigo Basal ganglia medicine Xerophthalmia Neurology (clinical) medicine.symptom business Depression (differential diagnoses) |
| Zdroj: | Neuro-Ophthalmology. 22:135-138 |
| ISSN: | 1744-506X 0165-8107 |
| Popis: | Primary Sjogren’s syndrome (PSS) is often associated with nervous system abnormalities, although opsoclonus as the dominant sign has not been reported before. In a 69-year-old woman with acute-onset opsoclonus as the dominant sign, ataxia, dysarthria, vertigo, depression, anxiety, and limb jerking, PSS was diagnosed based on xerophthalmia, xerostomia, increased anti-nuclear antibodies, a positive Schirmer’s test, and a pathologic salivary gland scintigraphy. Cerebral MRI revealed multiple, hyperintense basal ganglia and brainstem lesions. Cerebral HMPAO-SPECT showed unilateral cerebellar hypometabolism. Muscle/nerve biopsy was compatible with axonal polyneuropathy. Corticosteroids improved the patient’s condition considerably. In conclusion, opsoclonus may be the dominant sign in PSS and responds well to corticosteroids. |
| Databáze: | OpenAIRE |
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