Effect of metabolitotropic therapy on metabolic blood indices in patients with stage 2 essential hypertension associated with cardiac ischemia and type 2 diabetes mellitus with different genotypes of PPARγ2 gene
| Autor: | L. P. Sydorchuk, S. V. Biletskyi, O. A. Petrynych, V. V. Boyko, T. V. Kazantseva |
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| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty biology business.industry Glutathione peroxidase Insulin medicine.medical_treatment Type 2 Diabetes Mellitus Lipid metabolism Essential hypertension medicine.disease chemistry.chemical_compound Endocrinology chemistry Catalase Internal medicine Genotype medicine biology.protein General Earth and Planetary Sciences Quercetin business General Environmental Science |
| Zdroj: | Bukovinian Medical Herald. 23:16-21 |
| ISSN: | 2413-0737 1684-7903 |
| DOI: | 10.24061/2413-0737.xxiii.4.92.2019.84 |
| Popis: | Objective — to study peculiarities of metabolic disorders in patients with stage 2 essential hypertension associated with cardiac ischemia and type 2 diabetes mellitus (DM2) depending on polymorphism of PPARγ2 gene and to examine the efficacy of their correction by means of Quercetin (Corvitin), a 5-lipoxygenase inhibitor, and Arginine hydrochloride (Tivortin), a NO donator, against the ground of basic therapy administration. Material and methods. The study included 62 patients with stage 2 essential hypertension of 1–3 degree associated with cardiac ischemia (effort angina of I–II functional class) and DM2. The efficacy of metabolitotropic therapy with administration of Quercetin (Corvitin) and Arginine hydrochloride (Tivortin) was examined on 35 patients depending on polymorphism of PPARγ2 gene. The indices of carbohydrate, lipid metabolism and oxidative-antioxidative system were investigated. Results. All the examined indices of metabolism, except glutathione peroxidase and catalase in patients with Pro/Pro genotypes, in the examined patients with stage 2 essential hypertension and DM2 with Pro/Pro and Pro/Ala genotypes of PPARγ2 gene differ from those of healthy individuals. Reliably higher (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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